[肝提取物对肝微粒体系统及中毒实验模型的影响]
[Liver extract effect on liver microsomal system and on an experimental model of intoxication].
作者信息
Benakis A, Corthay J, Medilanski P, Dormard Y, Lévy J C
出版信息
C R Seances Soc Biol Fil. 1977;171(2):322-9.
PMID:142549
Abstract
A lyophilized liver extract (FLR) lengthens hexobarbital action in control rats ; it decreases slightly the induction of hepatic microsomal enzymes and normalizes diphenylhydantoin protection against electroshock seizure in phenobarbital-treated animals ; in the event of a CC14 intoxication, this extract reestablishes values close to normal for mebubarbital metabolism in mice and for BSP clearance in rats. FLR could act in regularizing drug metabolism.
摘要
冻干肝提取物（FLR）可延长正常大鼠体内己巴比妥的作用时间；它能轻微降低肝微粒体酶的诱导作用，并使苯巴比妥处理的动物体内苯妥英对电休克惊厥的保护作用恢复正常；在四氯化碳中毒的情况下，这种提取物能使小鼠中甲戊巴比妥代谢以及大鼠中磺溴酞钠清除率的值恢复接近正常水平。FLR可能在调节药物代谢方面发挥作用。
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