胃肠道微生物群在术后粘连形成中的作用——一项在无菌大鼠中的研究。

The role of the gastrointestinal microflora in postsurgical adhesion formation--a study in germfree rats.

作者信息

Bothin C, Midtvedt T

机构信息

Department of Surgery, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

出版信息

Eur Surg Res. 1992;24(5):309-12. doi: 10.1159/000129221.

DOI:10.1159/000129221

PMID:1425829

Abstract

The elucidation of the pathogenesis of postsurgical adhesion formation is still lacking. In this study experimental adhesion formation was studied in germfree (i.e. void of bacteria) and conventional rats (intestinal flora comprising over 400 species) using a caecal crush model. The germfree rats responded significantly weaker to the same stimuli, forming adhesions in only 20% of the cases as compared to the conventional rats 87.5% (p = 0.0076). The findings indicate that the bowel flora is of importance but not essential for postsurgical adhesion formation in rats.

摘要

目前仍缺乏对术后粘连形成发病机制的阐明。在本研究中，使用盲肠挤压模型，在无菌（即无细菌）大鼠和常规大鼠（肠道菌群包含400多种细菌）中研究了实验性粘连的形成。无菌大鼠对相同刺激的反应明显较弱，与常规大鼠87.5%的粘连形成率相比，无菌大鼠只有20%形成粘连（p = 0.0076）。研究结果表明，肠道菌群对大鼠术后粘连形成很重要，但并非必不可少。