流式细胞术在浅表性膀胱癌中的预后作用。

Prognostic role of flow cytometry in superficial bladder cancer.

作者信息

Di Silverio F, von Heland M, De Berardinis E, Izzi R, Buscarini M, De Vita R, Forte R, Seccareccia F, Menotti A

机构信息

Department of Urology, University La Sapienza, Rome, Italy.

出版信息

Eur Urol. 1992;21 Suppl 1:22-5. doi: 10.1159/000474882.

DOI:10.1159/000474882

PMID:1425833

Abstract

Prognostic factors in superficial transitional cell carcinoma of the bladder were assessed with histopathological and flow cytometry analysis in a series of 61 patients operated transurethrally between 1988 and 1990. In particular, we evaluated the usefulness of flow cytometry in order to identify patients who require a more accurate clinical follow-up or a more aggressive therapy. A multivariate analysis was done in 61 cases, considering patient age and sex, stage, grade and number of lesions (unifocal or multifocal), post-TUR therapy (therapy or not), and DNA ploidy (diploid/aneuploid). DNA pattern and number of recurrences were determinant for selecting risk cases for progression.

摘要

1988年至1990年间，对61例行经尿道手术的患者，采用组织病理学和流式细胞术分析评估膀胱浅表性移行细胞癌的预后因素。特别是，我们评估了流式细胞术在识别需要更精确临床随访或更积极治疗的患者方面的实用性。对61例患者进行了多因素分析，考虑了患者的年龄和性别、分期、分级、病变数量（单灶或多灶）、经尿道切除术后治疗（是否治疗）以及DNA倍体（二倍体/非整倍体）。DNA模式和复发次数是选择进展风险病例的决定因素。