Corrado F, Mannini D, Ferri C, Corrado G, Bertoni F, Bacchini P, Lieber M M, Song J M
Divisione di Urologia I, Ospedale Policlinico S. Orsola-Malpighi, Bologna, Italia.
Eur Urol. 1992;21 Suppl 1:48-50. doi: 10.1159/000474889.
Among 190 patients operated on for transitional cell cancer of the renal pelvis and/or ureter from 1976 to 1990, 95 had their tumor studied by flow cytometry. Of these, the prognostic significance of the DNA ploidy pattern with respect to the standard pathologic features was assessed in a retrospective analysis, where survival information were updated to October 1991 and the mean follow-up of patients exceeded 5.5 years (longest follow-up: 15.5 years). Five and ten-year survival probabilities for the whole group were, respectively, 65.5 and 51%. Patients with a diploid tumor had significantly better survival rates than patients with tetraploid/aneuploid cancer (p less than 0.00001). The impact of the DNA ploidy on survival was confirmed by a multivariate analysis of prognostic factors, where only tumor grade (p less than 0.0001), tumor stage (p less than 0.0001), number of neoplastic foci (p = 0.022) and nuclear DNA pattern (p less than 0.068) had a significant influence on survival. In the group of patients with low-stage (pTa-pT1) and low-grade (G1-G2) transitional cell cancer of the upper urinary tract, the DNA analysis was unable to identify any subset of patients at higher risk for disease progression.
在1976年至1990年间接受肾盂和/或输尿管移行细胞癌手术的190例患者中，95例患者的肿瘤接受了流式细胞术研究。在这些患者中，通过回顾性分析评估了DNA倍体模式相对于标准病理特征的预后意义，其中生存信息更新至1991年10月，患者的平均随访时间超过5.5年（最长随访时间：15.5年）。整个组的5年和10年生存概率分别为65.5%和51%。二倍体肿瘤患者的生存率明显高于四倍体/非整倍体癌症患者（p<0.00001）。通过对预后因素的多因素分析证实了DNA倍体对生存的影响，其中只有肿瘤分级（p<0.0001）、肿瘤分期（p<0.0001）、肿瘤病灶数量（p = 0.022）和核DNA模式（p<0.068）对生存有显著影响。在上尿路低分期（pTa-pT1）和低分级（G1-G2）移行细胞癌患者组中，DNA分析无法识别出任何疾病进展风险较高的患者亚组。
