Satoh S, Suzuki Y, Harada T, Ikegaki I, Asano T, Shibuya M, Sugita K, Hidaka H
Department of Neurosurgery, Nagoya University School of Medicine, Japan.
Eur J Pharmacol. 1992 Sep 22;220(2-3):243-8. doi: 10.1016/0014-2999(92)90754-r.
We examined the possible prophylactic potential of HA1077, a calcium antagonist and vasodilator, on chronic cerebral vasospasm induced in a two-hemorrhage canine model, and also its effects on cerebral hemodynamics. The intravenous infusion of HA1077 3 mg/kg over 30 min twice daily (day 1-day 7) after the first intracisternal injection of 5 ml autologous blood significantly prevented the occurrence of chronic cerebral vasospasm. The mean diameter of the basilar arteries on day 7 was 66.1 +/- 1.6% (n = 7) of the baseline before the intracisternal injection of blood, compared to 54.2 +/- 1.6% (n = 9) of the baseline in the untreated group (P less than 0.01). Bolus intravenous administration of HA1077 (0.1 and 0.3 mg/kg) dose dependently increased local cerebral blood flow. Since HA1077 prevents the development of chronic cerebral vasospasm after subarachnoid hemorrhage and improves hemodynamic functions, as manifested by increases in local cerebral blood flow, further study is warranted regarding the possible clinical use of this drug.
我们研究了钙拮抗剂及血管扩张剂HA1077对双次出血犬模型中慢性脑血管痉挛的潜在预防作用，以及其对脑血流动力学的影响。在首次脑池内注射5ml自体血后，每天两次、每次30分钟静脉输注3mg/kg的HA1077（第1天至第7天），可显著预防慢性脑血管痉挛的发生。第7天时，基底动脉的平均直径为脑池内注射血液前基线的66.1±1.6%（n = 7），而未治疗组为基线的54.2±1.6%（n = 9）（P<0.01）。静脉推注HA1077（0.1和0.3mg/kg）可剂量依赖性地增加局部脑血流量。由于HA1077可预防蛛网膜下腔出血后慢性脑血管痉挛的发生，并改善血流动力学功能，表现为局部脑血流量增加，因此有必要对该药物的临床应用可能性进行进一步研究。
