在体外受精/配子输卵管内移植（IVF/GIFT）方案中，阴道用黄体酮作为黄体期支持治疗。

Vaginal progesterone as luteal phase support in an IVF/GIFT programme.

作者信息

Polson D W, Rogers P A, Krapez J A, Leeton J F

机构信息

Monash IVF Programme, Infertility Medical Centre, Richmond, Victoria, Australia.

出版信息

Eur J Obstet Gynecol Reprod Biol. 1992 Aug 21;46(1):35-8. doi: 10.1016/0028-2243(92)90276-5.

DOI:10.1016/0028-2243(92)90276-5

PMID:1426499

Abstract

To determine whether luteal phase support with vaginal progesterone could improve pregnancy rates in our IVF/GIFT programme, we performed a prospective randomised controlled study. After stimulation with clomiphene citrate/human menopausal gonadotrophin, 123 women received no luteal support and 122 received progesterone pessaries 100 mg b.d. from 48 hours prior to embryo transfer and continued throughout the luteal phase. There was no difference in the pregnancy rate following IVF/ET (6/58 and 10/58 for the pessary and control group respectively), but a significantly higher rate was noted for GIFT (13/34 and 5/42 for the pessary and control group respectively; P less than 0.05). Of interest, only one of the 19 pregnancies using luteal support was extra-uterine, compared with 6/15 in the control group.

摘要

为了确定在我们的体外受精/配子输卵管内移植（IVF/GIFT）项目中，使用阴道孕酮进行黄体期支持是否能提高妊娠率，我们进行了一项前瞻性随机对照研究。在使用枸橼酸氯米芬/人绝经期促性腺激素进行刺激后，123名女性未接受黄体支持，122名女性从胚胎移植前48小时开始每天两次接受100毫克孕酮阴道栓剂，并在整个黄体期持续使用。体外受精/胚胎移植（IVF/ET）后的妊娠率没有差异（阴道栓剂组和对照组分别为6/58和10/58），但配子输卵管内移植（GIFT）的妊娠率显著更高（阴道栓剂组和对照组分别为13/34和5/42；P小于0.05）。有趣的是，在接受黄体支持的19次妊娠中只有1次是宫外妊娠，而对照组为6/15。