Frølich A, Rudnicki M, Storm T, Rasmussen N, Hegedüs L
Mineral Metabolic Research Group, Copenhagen, Denmark.
Eur J Obstet Gynecol Reprod Biol. 1992 Oct 23;47(1):25-9. doi: 10.1016/0028-2243(92)90210-p.
The aim of the study was to evaluate the calcium metabolism in pregnancy-induced hypertension. Fifty-three women with pregnancy-induced hypertension were studied and the control groups comprised 20 women with uncomplicated pregnancies in the third trimester and 51 non-pregnant women, respectively. The mean serum concentrations of 1,25-dihydroxyvitamin D in women with pregnancy-induced hypertension was low (38.6 +/- 21.4 pg/ml) compared to women with uncomplicated pregnancies (91.0 +/- 18.2 pg/ml), but comparable to levels in non-pregnant women (32.2 +/- 11.9 pg/ml). Mean serum levels of PTH and ionized calcium were comparable in women with pregnancy-induced hypertension and women with uncomplicated pregnancies. In conclusion, the calcium metabolism in pregnancy-induced hypertension was changed compared to uncomplicated pregnancies with respect to the serum concentration of 1,25-dihydroxyvitamin D.
本研究的目的是评估妊娠期高血压疾病中的钙代谢情况。对53例妊娠期高血压疾病患者进行了研究，对照组分别包括20例孕晚期无并发症的孕妇和51例非孕妇。与无并发症的孕妇（91.0±18.2 pg/ml）相比，妊娠期高血压疾病患者血清1,25-二羟维生素D的平均浓度较低（38.6±21.4 pg/ml），但与非孕妇的水平相当（32.2±11.9 pg/ml）。妊娠期高血压疾病患者和无并发症的孕妇的甲状旁腺激素（PTH）和离子钙的平均血清水平相当。总之，与无并发症的妊娠相比，妊娠期高血压疾病患者的钙代谢在血清1,25-二羟维生素D浓度方面发生了改变。
