Hughes S P, Benson M K, Ell P J, Britton K E
Rofo. 1977 Jun;126(6):551-5. doi: 10.1055/s-0029-1230635.
The early detection of metastatic spread in sixteen patients with osteosarcoma has been studied over a twelve month period, comparing the techniques of bone scanning and radiography. In only two patients were we able to demonstrate changes suggestive of pulmonary metastases any earlier with a 99mTc-EHDP scan than with chest radiographs and one of these resolved spontaneously. However, the bone scan did accurately delineate the extent of the primary tumour and may, therefore, be helpful in deciding the level of the amputation and the response of the patient to treatment, particularly now that chemotherapy and immunotherapy are frequently used in the management of the disease.
在十二个月的时间里，对16例骨肉瘤患者转移扩散的早期检测进行了研究，比较了骨扫描和放射照相技术。只有两名患者通过99mTc-EHDP扫描比胸部X光片更早发现提示肺转移的变化，其中一名患者的病变自发消退。然而，骨扫描确实准确地描绘了原发肿瘤的范围，因此，在决定截肢水平和患者对治疗的反应方面可能会有所帮助，特别是现在化疗和免疫疗法经常用于该疾病的治疗。
