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[利用数学模型确定工作场所空气中羧酸衍生物的最高容许暴露限值]

[The establishment of the MPEL for carboxylic acid derivatives in the air of a work area by using mathematical models].

作者信息

Gurova A I, Smoliar N Ia, Drozhzhina N A

出版信息

Gig Tr Prof Zabol. 1992(5):36-8.

PMID:1427353
Abstract

Reports of MACs for carboxylic acid derivatives as sodium methoxyacetate (SMOA), methyl chlorpropionate (MCP) and acetoacetic ether (AAE). SMOA shows low toxicity, no cumulation and specific action MCP demonstrates moderate toxicity, low cumulation no specific action in concentrations close to Limac. AAE presents toxicity low in oral usage and moderate when inhaled, low cumulation, no irritation and sensitization. Tentative safe level of injury and MAC estimated for the aforesaid substances together with toxicity parameters compared with the substances studied before allowed the authors to set the MAC of SMOA--10, MCP--2, AAE--10 mg/m3.

摘要

关于羧酸衍生物甲氧基乙酸钠(SMOA)、氯丙酸甲酯(MCP)和乙酰乙酸乙酯(AAE)的最大允许浓度(MAC)报告。SMOA毒性低、无蓄积且有特效作用;MCP显示中等毒性、低蓄积性,在接近阈浓度时无特效作用;AAE口服毒性低,吸入时毒性中等,蓄积性低,无刺激和致敏作用。通过对上述物质暂定的安全损伤水平和MAC进行估计,并将其毒性参数与之前研究的物质进行比较,作者确定SMOA的MAC为10mg/m³,MCP为2mg/m³,AAE为10mg/m³。

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