Masini L, Salvarani C, Macchioni P, Baldi G, Rossi F, Croci G, Prandi S, Davoli C, Portioli I, Gobbi F
I Divisione Medica, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
Haematologica. 1992 May-Jun;77(3):277-9.
A case of chronic neutrophilic leukemia (CNL), a rare myeloproliferative syndrome associated with monoclonal gammopathy of uncertain significance (MGUS-Type IgGk), is reported. Karyotypic study, carried out on bone marrow, excluded Philadelphia-pos. chronic myeloid leukemia (CML) and showed Y loss (45 XO). Only a few cases of CNL with paraproteinemia have been reported, but no case of associated karyotypic abnormalities and paraproteinemia has so far been described.
报告了1例慢性中性粒细胞白血病（CNL），这是一种罕见的骨髓增殖性综合征，与意义未明的单克隆丙种球蛋白病（MGUS型IgGk）相关。对骨髓进行的核型研究排除了费城染色体阳性的慢性髓性白血病（CML），并显示Y染色体缺失（45，XO）。仅有少数伴有副蛋白血症的CNL病例被报道，但迄今为止，尚未有伴有核型异常和副蛋白血症的病例被描述。
