Takeuchi T, Seki M, Hasegawa Y, Tsuchiya K, Itoh M, Itoh I, Shinozaki H, Jujo T, Ibuki Y, Igarashi M
Department of Obstetrics and Gynecology, Gunma University School of Medicine, Maebashi, Japan.
Horm Res. 1992;37 Suppl 1:69-74. doi: 10.1159/000182356.
Serum immunoreactive inhibin of the luteal phase was measured by radioimmunoassay in 71 patients in vitro fertilization and embryo transfer (IVF-ET). The correlation between the pregnancy outcome and the serial inhibin pattern from the luteal phase to early gestation was studied. In nonconception cycles (n = 35), serum inhibin concentration rose and reached a peak level around 5 or 6 days after oocyte pick-up (OPU), then fell to the level of the early follicular phase. In conception cycles (n = 22), serum inhibin levels rose again 10-15 days after OPU. Serum inhibin levels were significantly higher from 10 days after OPU in multiple pregnancy (n = 5) than in single pregnancy (n = 17). In viable single pregnancy (n = 17), serum inhibin levels were significantly higher than in non-viable pregnancy (n = 14) from 15 days after OPU. Serum inhibin levels in early gestation correlated well with the pregnancy outcome of IVF-ET. These data suggest that inhibin is an important factor for the diagnosis of pregnancy outcome.
采用放射免疫分析法测定了71例行体外受精-胚胎移植（IVF-ET）患者黄体期血清免疫反应性抑制素。研究了妊娠结局与黄体期至妊娠早期抑制素系列变化模式之间的相关性。在未受孕周期（n = 35）中，血清抑制素浓度在取卵（OPU）后约5或6天升高并达到峰值水平，然后降至卵泡早期水平。在受孕周期（n = 22）中，OPU后10 - 15天血清抑制素水平再次升高。多胎妊娠（n = 5）中OPU后10天起血清抑制素水平显著高于单胎妊娠（n = 17）。在单胎活产妊娠（n = 17）中，OPU后15天起血清抑制素水平显著高于非活产妊娠（n = 14）。妊娠早期血清抑制素水平与IVF-ET的妊娠结局密切相关。这些数据表明，抑制素是诊断妊娠结局的一个重要因素。
