Rice T, Nirmala A, Reddy P C, Ramana P V, Krishna K S, Rao D C
Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110.
Hum Biol. 1992 Dec;64(6):869-89.
Familial aggregation of blood pressure (BP), both systolic (SBP) and diastolic (DBP), was examined in consanguineous and nonconsanguineous families from southern India. Path analysis of BP suggests inbreeding effects, with the genetic variance for SBP being lower in the sample that included inbred families. Specifically, genetic heritability for SBP was 38% in the nonconsanguineous sample but only 23% in the combined sample. Genetic heritability for DBP (30%) did not vary by sample, nor were sample differences in cultural heritability detected for either SBP (over 35%) or DBP (about 18%). These findings are remarkably similar to those in a French-Canadian population of Quebec; both reports found a considerably larger effect of the home environment on BP than previous studies.
在印度南部的近亲家庭和非近亲家庭中，研究了收缩压（SBP）和舒张压（DBP）的家族聚集性。血压的路径分析表明存在近亲繁殖效应，在包含近亲家庭的样本中，SBP的遗传方差较低。具体而言，非近亲样本中SBP的遗传 heritability 为38%，但在合并样本中仅为23%。DBP的遗传 heritability（30%）在不同样本中没有变化，对于SBP（超过35%）或DBP（约18%），也未检测到文化 heritability 的样本差异。这些发现与魁北克法裔加拿大人人群中的发现非常相似；两份报告均发现家庭环境对血压的影响比以往研究大得多。
