Majumder P P, Das R N, Nayak S, Bhattacharya S K, Mukherjee B N
Anthropometry and Human Genetics Unit, Indian Statistical Institute, Calcutta, India.
Hum Biol. 1995 Dec;67(6):827-42.
A genetic epidemiological study of blood pressure was conducted in two contrasting populations: the Marwaris of Calcutta and the Hindu middle-caste agriculturists of Digha. The Marwaris are heavier and significantly more obese than the agriculturists. The prevalence of hypertension among the Marwaris (17%) is more than tenfold higher than that among the agriculturists (1.4%). Genetic analysis of blood pressure data using a path model indicates that blood pressure levels (adjusted and standardized for age, gender, education level, and disease status) are primarily determined by environmental factors, as measured by their effects on anthropometric characters. The observed familial resemblance of blood pressure levels in the two populations is primarily due to cultural rather than genetic inheritance. Genetic and familial effects on covariation between anthropometric measures of obesity and blood pressure levels are perhaps so strong that there is no residual genetic heritability of adjusted blood pressure levels.
加尔各答的马尔瓦尔人和迪加的印度教中种姓农业从业者。马尔瓦尔人比农业从业者体重更重，肥胖程度也显著更高。马尔瓦尔人高血压患病率（17%）比农业从业者（1.4%）高出十多倍。使用路径模型对血压数据进行的遗传分析表明，血压水平（针对年龄、性别、教育水平和疾病状况进行调整和标准化）主要由环境因素决定，环境因素通过其对人体测量特征的影响来衡量。在这两个人群中观察到的血压水平的家族相似性主要归因于文化而非遗传继承。肥胖的人体测量指标与血压水平之间的协变的遗传和家族效应可能非常强烈，以至于调整后的血压水平不存在残余遗传力。
