狒狒中C3与LDLR以及APOA4与APOA1基因座之间的连锁异质性。

Linkage heterogeneity between the C3 and LDLR and the APOA4 and APOA1 loci in baboons.

作者信息

Kammerer C M, Hixson J E, Aivaliotis M J, Porter P A, VandeBerg J L

机构信息

Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228-0147.

出版信息

Genomics. 1992 Sep;14(1):43-8. doi: 10.1016/s0888-7543(05)80281-2.

DOI:10.1016/s0888-7543(05)80281-2

PMID:1427832

Abstract

We detected linkage in baboons between loci for the third component of complement (C3) and the low-density lipoprotein receptor (LDLR), lod score = 5.53, and loci for apolipoprotein A1 (APOA1) and apolipoprotein AIV (APOA4), lod score = 14.59. We also found evidence for linkage heterogeneity among the baboon pedigrees between LDLR and C3 (P = 0.04) and between APOA1 and APOA4 (P = 0.01).

摘要

我们在狒狒中检测到补体第三成分（C3）基因座与低密度脂蛋白受体（LDLR）基因座之间存在连锁，连锁值 = 5.53，以及载脂蛋白A1（APOA1）基因座与载脂蛋白AIV（APOA4）基因座之间存在连锁，连锁值 = 14.59。我们还发现，在狒狒家系中，LDLR与C3之间（P = 0.04）以及APOA1与APOA4之间（P = 0.01）存在连锁异质性的证据。