Plougastel B, Couillin P, Blanquet V, Le Guern E, Bakker E, Turleau C, De Grouchy J, Créau-Goldberg N
U173 INSERM, Hôpital Necker Enfants Malades, Paris, France.
Genomics. 1992 Oct;14(2):523-5. doi: 10.1016/s0888-7543(05)80259-9.
Cellular hybrids were obtained from a t(X;12) identified in a female patient with hypohidrotic ectodermal dysplasia (EDA). This rearrangement had the same Xq13.1 cytogenetic breakpoint as a t(X;9) found in a previously observed EDA patient. A comparative analysis of these two rearrangements with nine probes was performed at the molecular level. These probes could define three subregions: three are proximal, two are distal, and four are between the two breakpoints. These last probes should prove useful for cloning the gene.
细胞杂种是从一名患有少汗性外胚层发育不良（EDA）的女性患者中鉴定出的t(X;12)获得的。这种重排与先前观察到的一名EDA患者中发现的t(X;9)具有相同的Xq13.1细胞遗传学断点。在分子水平上对这两种重排与九个探针进行了比较分析。这些探针可以定义三个子区域：三个是近端的，两个是远端的，四个在两个断点之间。最后这些探针应该对克隆该基因有用。
