用来自耐受供体的胸腺移植到经胸腺切除、照射的大鼠体内后的免疫耐受。

IMMUNOLOGIC TOLERANCE IN THYMECTOMIZED, IRRADIATED RATS GRAFTED WITH THYMUS FROM TOLERANT DONORS.

作者信息

ISAKOVIC K, SMITH S B, WAKSMAN B H

出版信息

Science. 1965 Jun 4;148(3675):1333-5. doi: 10.1126/science.148.3675.1333.

DOI:10.1126/science.148.3675.1333

Abstract

Lewis rats, thymectomized at 5 weeks of age and irradiated at 8 weeks, received grafts of adult thymus and marrow, one or both grafts being derived from donors tolerant to bovine gamma-globulin. Challenge 3 or 6 weeks after grafting showed that delayed sensitization could not be induced in animals which received a tolerant thymus or tolerant thymus and marrow, though sensitization to a heterologous antigen (chicken ovalbumin) occurred normally. Arthus reactivity was regained slowly in animals receiving normal thymus and marrow and, to an equal extent, in those receiving grafts from tolerant donors.

摘要

5周龄时进行胸腺切除、8周龄时接受照射的Lewis大鼠，接受了成年胸腺和骨髓移植，其中一个或两个移植组织均来自对牛γ球蛋白耐受的供体。移植后3周或6周进行激发试验，结果显示，接受耐受胸腺或耐受胸腺及骨髓的动物无法诱导出迟发型超敏反应，不过对异种抗原（鸡卵白蛋白）的致敏反应正常发生。接受正常胸腺和骨髓移植的动物以及接受来自耐受供体移植组织的动物，其阿瑟斯反应均缓慢恢复，且恢复程度相同。