Bansal V P, Mittal P K, Ashokraj G
Central Institute of Orthopaedics, New Delhi, India.
Int Orthop. 1992;16(3):297-301. doi: 10.1007/BF00182716.
Fifty-three patients with osteomyelitis were grouped according to the duration of the disease at presentation, the bone and the part involved, the aetiology, activity, severity and stage of disease. Sera from these patients was estimated for IgA, IgM and IgG levels and in 23 matched controls. The results were compared with the normal range, and correlative studies were carried out between serum immunoglobulin levels and the different clinical parameters. Serum levels of the 3 immunoglobulins were found, in general, to fail to rise above the normal in the presence of infection. Furthermore, the levels did not show significant variation with the clinical parameters. These findings suggest that there is an intrinsically subdued immune response to osteomyelitis in most of the patients, partly confirming the suspicion of an immunodeficient state.
53例骨髓炎患者根据就诊时疾病的持续时间、受累骨骼及部位、病因、活动度、严重程度和疾病分期进行分组。检测了这些患者以及23名匹配对照者血清中的IgA、IgM和IgG水平。将结果与正常范围进行比较，并对血清免疫球蛋白水平与不同临床参数进行相关性研究。结果发现，一般情况下，感染时这3种免疫球蛋白的血清水平未能升高至正常范围以上。此外，这些水平与临床参数之间未显示出显著差异。这些发现表明，大多数患者对骨髓炎存在内在的免疫反应抑制，部分证实了对免疫缺陷状态的怀疑。
