Beniwal B K, Hastings I M, Thompson R, Hill W G
Institute of Cell, Animal and Population Biology, University of Edinburgh.
Heredity (Edinb). 1992 Oct;69 ( Pt 4):352-60. doi: 10.1038/hdy.1992.135.
Analysis was undertaken using Restricted Maximum Likelihood (REML) with an animal model of the results of selection for 20 generations for predicted lean mass in 10-week-old male mice. There were three replicates, each comprising high, low and unselected control lines. The overall estimates of heritability (h2) and common environmental correlations (c2) from results of the first seven generations were 0.51 +/- 0.03 and 0.21 +/- 0.01, respectively. Analyses of data from different lines and different numbers of generations were undertaken but with all pedigrees and data included, which enabled inferences to be drawn on changes in variance that were not due simply to inbreeding or short-term effects of selection. Estimates of h2 were lower in selected lines than the control, increasingly so in later generations, indicating departure from the infinitesimal model assumption of unlinked additive genes each of very small effect. In addition, values of c2 became higher in high than in control or low selected lines.
使用限制最大似然法（REML）对10周龄雄性小鼠预测瘦肉量进行20代选择结果的动物模型分析。有三个重复，每个重复包括高、低和未选择的对照品系。前七代结果的遗传力（h2）和共同环境相关性（c2）的总体估计分别为0.51±0.03和0.21±0.01。对来自不同品系和不同代数的数据进行了分析，但纳入了所有系谱和数据，这使得能够推断出并非仅仅由于近亲繁殖或选择的短期效应而导致的方差变化。选择品系中的h2估计值低于对照品系，在后代中越来越低，表明偏离了无连锁加性基因的无穷小模型假设，每个基因的效应都非常小。此外，高选择品系中的c2值高于对照品系或低选择品系。
