亨廷顿舞蹈症症状前携带者的检测。

Detection of presymptomatic carriers of Huntington's chorea.

作者信息

Rosenberg S, Metzig E, Snider S R, Ast M, Tobin D

出版信息

Neuropsychobiology. 1977;3(2-3):144-52. doi: 10.1159/000117599.

Abstract

Laterality of thumb opposition and handedness were determined in three groups of subjects: patients with Huntington's chorea (n = 18), asymptomatic offspring of patients (n = 40), and asymptomatic siblings of patients over 50 years of age termed 'escapees' (n = 17). 100% of patients and 55% of young at-risk offspring had crossed laterality of thumb opposition and handedness. Only 2 (11.8%) of the 'escapees' had crossed laterality. Crossed laterality may be associated with symptomatic presymptomatic Huntington's chorea.

摘要

在三组受试者中确定了拇指对掌的偏向性和利手情况

患有亨廷顿舞蹈症的患者（n = 18）、患者的无症状后代（n = 40）以及50岁以上被称为“未患病者”的患者无症状兄弟姐妹（n = 17）。100%的患者和55%的年轻高危后代存在拇指对掌偏向性和利手交叉的情况。只有2名（11.8%）“未患病者”存在偏向性交叉。偏向性交叉可能与有症状的症状前亨廷顿舞蹈症有关。