Santerre J P, ten Hove P, Brash J L
Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.
J Biomed Mater Res. 1992 Aug;26(8):1003-18. doi: 10.1002/jbm.820260804.
Segmented polyurethanes based on 4,4'-diphenylmethane diisocyanate and polypropylene oxide and chain extended with a sulfonated diamine were derivatized by reaction of sulfonate groups in the polymer with amino acids. The chemical composition of the derivatized polymers was determined by elemental analysis. Tensile stress-strain measurements indicated a slight increase in modulus and elongation with incorporation of amino acids. Water uptake at room temperature showed little change following derivatization, but at 70 degrees C increased significantly. Water contact angles were not influenced by the presence of amino acids, but electron spectroscopy for chemical analysis data showed an increase in hard segment content in the near-surface layers so that bulk and surface compositions were more nearly the same in the amino-acid-containing materials. Fibrinogen adsorption from plasma, shown previously to be high on the sulfonated polyurethanes, was reduced by derivatization, due probably to the decrease in free sulfonate content. Thrombin times of plasma in contact with these materials were essentially the same for the derivatized and underivatized materials.
基于4,4'-二苯基甲烷二异氰酸酯和聚环氧丙烷并经磺化二胺扩链的嵌段聚氨酯，通过聚合物中的磺酸根基团与氨基酸反应进行衍生化。衍生化聚合物的化学组成通过元素分析确定。拉伸应力-应变测量表明，随着氨基酸的引入，模量和伸长率略有增加。室温下的吸水率在衍生化后变化不大，但在70℃时显著增加。水接触角不受氨基酸存在的影响，但化学分析数据的电子能谱显示近表面层硬段含量增加，因此含氨基酸材料的本体和表面组成更接近相同。先前已表明在磺化聚氨酯上纤维蛋白原从血浆中的吸附很高，衍生化后吸附减少，这可能是由于游离磺酸盐含量降低所致。与这些材料接触的血浆的凝血酶时间，衍生化材料和未衍生化材料基本相同。
