Winter J C
Psychopharmacology (Berl). 1977 Jul 18;53(2):159-63. doi: 10.1007/BF00426486.
It is well established that the effects of morphine and ethanol can function as discriminative stimuli in the rat. The present investigation sought to determine whether discriminated responding mediated by morphine and ethanol is affected by (a) p-chlorophenylalanine methyl ester (p-CPA) an inhibitor of the synthesis of 5-hydroxytryptamine (5-HT) and (b) antagonists of 5-HT. The blocking agents employed were cinanserin, in ethanol-trained subjects, and BC-105, in morphine-trained subjects. No evidence of antagonism was obtained with either BC-105 or cinanserin. Results with p-CPA were somewhat variable but no consistent or statistically significant reduction in the efficacy of morphine or ethanol as discriminative stimuli was observed. The present results with p-CPA are at variance with earlier work by Schechter (1973) and by Rosecrans et al. (1973) who observed antagonism of the stimulus effects of ethanol and morphine, respectively, following depletion of 5-HT with p-chlorophenylalanine.
吗啡和乙醇的作用能够在大鼠中充当辨别性刺激，这一点已得到充分证实。本研究旨在确定由吗啡和乙醇介导的辨别性反应是否会受到以下因素的影响：(a) 对氯苯丙氨酸甲酯（p-CPA），一种5-羟色胺（5-HT）合成的抑制剂；以及(b) 5-HT拮抗剂。所使用的阻断剂在乙醇训练的实验对象中为辛那色林，在吗啡训练的实验对象中为BC-105。无论是BC-105还是辛那色林，均未获得拮抗作用的证据。p-CPA的实验结果有些多变，但未观察到吗啡或乙醇作为辨别性刺激的效力出现一致的或具有统计学意义的降低。目前关于p-CPA的结果与Schechter（1973年）以及Rosecrans等人（1973年）的早期研究结果不同，他们分别观察到在用对氯苯丙氨酸耗尽5-HT后，乙醇和吗啡的刺激作用出现了拮抗。
