Winter J C
Arch Int Pharmacodyn Ther. 1975 Apr;214(2):250-3.
It is known that the effects of mescaline (3, 4, 5-trimethoxyphenylethylamine), a hallucinogen, can function as a discriminative stimulus. The present investigation examined the ability of cinanserin, a serotinin antagonist, to block the stimulus properties of mescaline in the rat. After a reliable discrimination was established between the effects following the injection of mescaline (10 mg/kg) and those following administration of saline, subjects were pretreated with cinanserin HC1 (3 mg/kg) and then treated with mescaline. Such pretreatment was found to block discrimination, i.e., the response rate following the administration of mescaline plus cinanserin was appropriate for the saline condition. The present data suggest that antagonists of serotonin may be useful in furthering our understanding of phenethylamine hallucinogens.
已知致幻剂三甲氧苯乙胺（3,4,5-三甲氧基苯乙胺）的作用可作为一种辨别刺激。本研究考察了5-羟色胺拮抗剂辛那色林阻断三甲氧苯乙胺对大鼠刺激效应的能力。在可靠区分注射三甲氧苯乙胺（10毫克/千克）后的效应与注射生理盐水后的效应后，对实验对象预先给予盐酸辛那色林（3毫克/千克），然后再给予三甲氧苯乙胺。发现这种预处理可阻断辨别，即给予三甲氧苯乙胺加辛那色林后的反应率与生理盐水条件下的反应率相当。目前的数据表明，5-羟色胺拮抗剂可能有助于我们进一步了解苯乙胺类致幻剂。
