Falcone T, Little A B, Morris D
Department of Medicine, Royal Victoria Hospital, Montreal, Quebec, Canada.
Hum Reprod. 1992 Aug;7(7):922-5. doi: 10.1093/oxfordjournals.humrep.a137771.
Insulin resistance and glucose intolerance are common features of polycystic ovary syndrome (PCOS). We have investigated the effect of glucose on the fractional glucose disappearance in patients with PCOS and in age- and weight-matched control subjects. The minimal model method as applied to a frequently sampled intravenous glucose tolerance test was employed. The insulin sensitivity index (Si) and glucose effectiveness (SG) were calculated with the MINMOD program. Testosterone, androstenedione and free testosterone concentrations were significantly higher in PCOS subjects. Glucose-induced glucose clearance (SG) and insulin sensitivity were significantly lower in PCOS subjects than controls [SG: 2.7 +/- 0.3 versus 1.8 +/- 0.1 x 100/min; P less than 0.01; Si: 133.4 +/- 20.0 versus 65.6 +/- 6.4/min (nmol/ml)]. Six PCOS women had an SG value within the normal range (greater than 2.0 x 100/min) but had a similar Si to that found in PCOS women with abnormal SG. We suggest that independent alterations in both glucose- and insulin-mediated glucose uptake occur in patients with PCOS. The underlying disturbance in glucose effectiveness may be similar to that found in familial non-insulin dependent diabetes mellitus.
胰岛素抵抗和葡萄糖耐量异常是多囊卵巢综合征（PCOS）的常见特征。我们研究了葡萄糖对PCOS患者以及年龄和体重匹配的对照受试者中葡萄糖分数消失率的影响。采用应用于频繁采样静脉葡萄糖耐量试验的最小模型法。使用MINMOD程序计算胰岛素敏感性指数（Si）和葡萄糖效能（SG）。PCOS受试者的睾酮、雄烯二酮和游离睾酮浓度显著更高。PCOS受试者中葡萄糖诱导的葡萄糖清除率（SG）和胰岛素敏感性显著低于对照组[SG：2.7±0.3对1.8±0.1×100/分钟；P<0.01；Si：133.4±20.0对65.6±6.4/分钟（纳摩尔/毫升）]。6名PCOS女性的SG值在正常范围内（大于2.0×100/分钟），但Si与SG异常的PCOS女性相似。我们认为，PCOS患者在葡萄糖介导和胰岛素介导的葡萄糖摄取方面均发生独立改变。葡萄糖效能的潜在紊乱可能与家族性非胰岛素依赖型糖尿病中发现的情况相似。
