Reynolds E H
Maudsley Hospital, London, UK.
J Neuroimmunol. 1992 Oct;40(2-3):225-30. doi: 10.1016/0165-5728(92)90137-a.
Multiple sclerosis (MS) is occasionally associated with vitamin B12 deficiency. Recent studies have shown an increased risk of macrocytosis, low serum and/or CSF vitamin B12 levels, raised plasma homocysteine and raised unsaturated R-binder capacity in MS. The aetiology of the vitamin B12 deficiency in MS is often uncertain and a disorder of vitamin B12 binding or transport is suspected. The nature of the association of vitamin B12 deficiency and MS is unclear but is likely to be more than coincidental. There is a remarkable similarity in the epidemiology of MS and pernicious anaemia. Vitamin B12 deficiency should always be looked for in MS. The deficiency may aggravate MS or impair recovery. There is evidence that vitamin B12 is important for myelin synthesis and integrity but further basic studies are required.
多发性硬化症（MS）偶尔与维生素B12缺乏有关。最近的研究表明，MS患者出现大细胞性贫血、血清和/或脑脊液维生素B12水平降低、血浆同型半胱氨酸升高以及不饱和R-结合蛋白能力升高的风险增加。MS中维生素B12缺乏的病因通常不确定，怀疑存在维生素B12结合或转运障碍。维生素B12缺乏与MS之间关联的性质尚不清楚，但可能不仅仅是巧合。MS和恶性贫血的流行病学有显著相似之处。在MS患者中应始终留意维生素B12缺乏情况。这种缺乏可能会加重MS或妨碍恢复。有证据表明维生素B12对髓鞘合成和完整性很重要，但还需要进一步的基础研究。
