Hayashi T, Onodera T, Yamamoto H
Laboratory of Veterinary Pathology, University of Yamaguchi, Japan.
J Comp Pathol. 1992 Jul;107(1):35-40. doi: 10.1016/0021-9975(92)90093-a.
This study showed that sera from mice chronically infected with lactic dehydrogenase virus (LDV) contained virus-antibody complexes (IC). IgG2a and IgG2b, but not IgG1, IgG3, IgM or IgA, were demonstrated on the surface of macrophages from chronically infected mice. These results suggest that IC in the circulation may bind to Fc receptors for IgG2a and IgG2b on the surface of macrophages and lead to the modulation of macrophage function seen in chronically LDV-infected mice.
这项研究表明，慢性感染乳酸脱氢酶病毒（LDV）的小鼠血清中含有病毒抗体复合物（IC）。在慢性感染小鼠的巨噬细胞表面检测到了IgG2a和IgG2b，但未检测到IgG1、IgG3、IgM或IgA。这些结果表明，循环中的IC可能与巨噬细胞表面IgG2a和IgG2b的Fc受体结合，并导致在慢性LDV感染小鼠中观察到的巨噬细胞功能调节。
