光泽苔藓的免疫组化检查表明它不是扁平苔藓的局限性丘疹型变种。
Immunohistochemical examination of lichen nitidus suggests that it is not a localized papular variant of lichen planus.
作者信息
Smoller B R, Flynn T C
机构信息
Department of Dermatology, Stanford University Medical Center, CA 94305.
出版信息
J Am Acad Dermatol. 1992 Aug;27(2 Pt 1):232-6. doi: 10.1016/0190-9622(92)70176-g.
BACKGROUND
Lichen nitidus is believed, by some, to be a variant of lichen planus, and by others to be a distinct entity.
OBJECTIVE
We examined five cases of lichen nitidus with immunohistochemical reagents designed to characterize the dermal inflammatory infiltrate in an attempt to resolve the uncertainty.
METHODS
We stained formalin-fixed, paraffin-embedded tissue sections with the following antibodies: L26, A6, KP1, BerH2, OPD4, and HECA-452.
RESULTS
The inflammatory infiltrate was 90% A6+, with few L26+ cells. In contrast to lichen planus, KP1+ macrophages were seen and fewer of the lymphocytes demonstrated HECA-452. Fifty percent to 80% of lymphocytes were OPD4 positive, similar to that usually seen in lichen planus. Rare Ki-1+ cells were seen in one case.
CONCLUSION
We believe that the pattern of a mixed cellular infiltrate characterized by macrophages and a helper T cell response with few HECA-452+ cells is somewhat different from the pattern seen in lichen planus, wherein almost all of the cells are CD4+/HECA-452+ lymphocytes. This suggests a different immunologic pathogenesis.
背景
一些人认为光泽苔藓是扁平苔藓的一种变体，而另一些人则认为它是一种独立的疾病。
目的
我们使用免疫组化试剂检查了5例光泽苔藓病例，旨在对真皮炎症浸润进行特征性分析，以解决这一不确定性。
方法
我们用以下抗体对福尔马林固定、石蜡包埋的组织切片进行染色：L26、A6、KP1、BerH2、OPD4和HECA-452。
结果
炎症浸润细胞90%为A6阳性，L26阳性细胞较少。与扁平苔藓不同，可见KP1阳性巨噬细胞，且较少淋巴细胞表现为HECA-452阳性。50%至80%的淋巴细胞OPD4阳性，这与扁平苔藓中通常所见情况相似。在1例病例中可见罕见的Ki-1阳性细胞。
结论
我们认为，以巨噬细胞和辅助性T细胞反应为特征的混合细胞浸润模式，且HECA-452阳性细胞较少，与扁平苔藓中所见模式有所不同，扁平苔藓中几乎所有细胞均为CD4+/HECA-452+淋巴细胞。这提示了不同的免疫发病机制。
Zotero 插件