Shukla S S, Honeyman J C, Crosson B, Williams C M, Nadeau S E
Veterans Administration Medical Center, Nuclear Medicine Service, Gainesville, FL 32608.
J Comput Assist Tomogr. 1992 Nov-Dec;16(6):966-70. doi: 10.1097/00004728-199211000-00025.
We have developed a simple method for locating functional regions of interest on successive SPECT scans obtained at different times and for locating neuroanatomical regions defined with MR on functional images obtained with SPECT. Plastic molds are made for each external auditory meatus and the glabella. A pocket is then made in each mold in which either a 57Co disk (for SPECT) or an identical disk containing CuSO4 solution (for MRI) can be placed. Transaxial tomographic slices are reconstructed with the same slice thickness in the two modalities. The SPECT software rotates both SPECT and MRI reconstructed images so that the three 57Co markers lie in one SPECT reference plane and the three CuSO4 markers lie in one MRI reference plane. Corresponding SPECT and MR images may then be displayed simultaneously to locate chosen regions of interest. The technique was validated by taping test markers to the forehead of 12 subjects; the difference between the positions of the centers of the test markers on SPECT and MR scans was within 1 SPECT acquisition pixel size.
我们已经开发出一种简单的方法，用于在不同时间获取的连续SPECT扫描上定位感兴趣的功能区域，并在SPECT获得的功能图像上定位由MR定义的神经解剖区域。为每个外耳道和眉间制作塑料模具。然后在每个模具中制作一个口袋，可在其中放置一个57Co盘（用于SPECT）或一个含有CuSO4溶液的相同盘（用于MRI）。在两种模态中以相同的切片厚度重建横断面断层切片。SPECT软件旋转SPECT和MRI重建图像，使三个57Co标记位于一个SPECT参考平面内，三个CuSO4标记位于一个MRI参考平面内。然后可以同时显示相应的SPECT和MR图像，以定位选定的感兴趣区域。通过将测试标记贴在12名受试者的前额上对该技术进行了验证；SPECT和MR扫描上测试标记中心位置的差异在1个SPECT采集像素大小范围内。
