[生育唐氏综合征患儿母亲的组织免疫功能可能存在的紊乱]

[Possible disorder of tissue immunity function in mothers who have given birth to a child with Down's disease].

作者信息

Davidenkova E F, Sokolova S M, Butomo I V, Khitrikova L E, Chukhlovin A B

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(6):863-5.

Abstract

The rates of DNA synthesis were studied in PHA-stimulated lymphocytes from the peripheral blood of mothers giving birth to a child with Down's disease. For control purposes a group of donors of the same age and sex were studied as wells. A decrease of 3H-thymidine incorporation was detected in the lymphocytes of the mothers of such children. The found differences were due to a drop of lymphocyte PH-reactivity in the older maternal age group (over 30 years). Interrelation between the changed function of the maternal immune system and the birth of children with chromosome unbalance are discussed.

摘要

对分娩唐氏病患儿的母亲外周血中经PHA刺激的淋巴细胞的DNA合成速率进行了研究。为作对照，还研究了一组年龄和性别相同的供血者。在这些患儿母亲的淋巴细胞中检测到3H-胸腺嘧啶核苷掺入减少。所发现的差异是由于年龄较大的母亲年龄组（超过30岁）中淋巴细胞的PHA反应性下降所致。文中讨论了母亲免疫系统功能改变与染色体不平衡患儿出生之间的相互关系。