van der Zwan A, Hillen B, Tulleken C A, Dujovny M, Dragovic L
Department of Neurological Surgery, University Hospital of Utrecht, The Netherlands.
J Neurosurg. 1992 Dec;77(6):927-40. doi: 10.3171/jns.1992.77.6.0927.
Recent morphological and functional studies on the circle of Willis suggest that the areas of supply of the six major cerebral arteries show a considerable variation in distribution, in contrast to the relatively consistent pattern generally accepted; therefore, the cortical and intracerebral distribution of the territories of these arteries was investigated in 25 unfixed human brains obtained at routine autopsy. The six major cerebral arteries were simultaneously injected under the same pressure with different-colored Araldite F mixtures under standardized conditions to obtain the most realistic territorial distribution. The cortical boundaries were examined and recorded in relation to the cerebral gyri and sulci, and the territories of the anterior, middle, and posterior cerebral arteries were analyzed and compared. The intracerebral distribution of these territories was investigated after the injected brains were cut in parallel slices. The variability of the territories of these arteries was much larger than generally described in the literature. Twenty-six variations in the territory of the anterior cerebral artery, 17 variations in the area of the middle cerebral artery, and 22 variations in the area of the posterior cerebral artery were found in the cortex of 50 hemispheres. Intracerebrally, the anterior, middle, and posterior cerebral arteries contributed in varying degrees to the blood supply of the lobar white matter, the internal capsule, the caudate nucleus, and the lentiform nucleus. The large variation in the area in which the cortical and intracerebral boundaries between these territories was located was demonstrated by illustrating the minimum and maximum extent of each. The results are compared with prior findings, and their implications for both experimental model studies and clinical practice are discussed.
最近对 Willis 环的形态学和功能研究表明，与普遍接受的相对一致的模式相反，六大脑动脉的供血区域在分布上存在相当大的差异；因此，在 25 个常规尸检获得的未固定人脑标本中，对这些动脉供血区域的皮质和脑内分布进行了研究。在标准化条件下，以相同压力同时用不同颜色的 Araldite F 混合物对六大脑动脉进行注射，以获得最真实的供血区域分布。检查并记录与脑回和脑沟相关的皮质边界，并对大脑前、中、后动脉的供血区域进行分析和比较。在将注射后的大脑切成平行切片后，研究这些区域的脑内分布。这些动脉供血区域的变异性比文献中通常描述的要大得多。在 50 个半球的皮质中，发现大脑前动脉供血区域有 26 种变异，大脑中动脉区域有 17 种变异，大脑后动脉区域有 22 种变异。在脑内，大脑前、中、后动脉对叶白质、内囊、尾状核和豆状核的血液供应有不同程度的贡献。通过说明每个区域的最小和最大范围，展示了这些区域之间皮质和脑内边界所在区域的巨大差异。将结果与先前的发现进行比较，并讨论其对实验模型研究和临床实践的意义。
