Lythgoe M F, Davies H, Kuba A, Toth-Abonyi M, Gordon I
Department of Radiology, Hospital for Sick Children, London, United Kingdom.
J Nucl Med. 1992 Nov;33(11):1935-9.
This study explores the assumption that 81mKr static images represent regional ventilation. Dynamic acquisition of 81mKr ventilation images permits creation of time-activity curves and the possible separation of the confounding influences of ventilation and volume. By using a two-compartment gas mixing lung phantom, the results demonstrate that both total and tidal 81mKr are closely related to regional ventilation. In 61 children and 15 adult volunteers, there was good agreement between fractional ventilation assessed by total and tidal 81mKr. The dynamic steady-state ventilation image can be analyzed to separate tidally exchanged and resident 81mKr. This may allow regional ventilation to be distinguished from regional volume.
本研究探讨了81mKr静态图像代表局部通气的假设。动态采集81mKr通气图像可生成时间-活性曲线，并有可能分离通气和容积的混杂影响。通过使用双室气体混合肺模型，结果表明，总81mKr和潮气81mKr均与局部通气密切相关。在61名儿童和15名成人志愿者中，通过总81mKr和潮气81mKr评估的通气分数之间具有良好的一致性。动态稳态通气图像可进行分析，以分离潮式交换的和滞留的81mKr。这可能有助于区分局部通气和局部容积。
