McDevitt G R, Heironimus J D, Toney M O, Billingsley J L
Brooke Army Medical Center, Fort Sam Houston, Texas.
J Nucl Med. 1992 Nov;33(11):2052-4.
Extra-skeletal uptake of bone seeking radiopharmaceuticals has been documented by scintigraphy. We present a case of diffuse uptake of 99mTc-methylene diphosphonate (MDP) in the abdomen of a patient while undergoing continuous ambulatory peritoneal dialysis (CAPD) who had no symptoms or findings referable to the abdomen. We hypothesized that the 99mTc-MDP crossed the peritoneal membrane across a concentration gradient. An in-vitro simulation confirms that 99mTc-MDP will cross a semi-permeable membrane. Diffuse uptake of 99mTc-MDP may be a normal variant in patients on CAPD who have no signs or symptoms of peritonitis.
骨显像剂的骨骼外摄取已通过闪烁扫描法得到记录。我们报告一例在持续非卧床腹膜透析（CAPD）过程中，99m锝-亚甲基二膦酸盐（MDP）在一名患者腹部弥漫性摄取的病例，该患者无腹部相关症状或体征。我们推测99mTc-MDP通过浓度梯度穿过腹膜。体外模拟证实99mTc-MDP会穿过半透膜。99mTc-MDP的弥漫性摄取在无腹膜炎体征或症状的CAPD患者中可能是一种正常变异。
