Luga A, Bayard F, Louvet J P, Mansat A, Bennet P, Moatti J P, Pontonnier F, Boulard C
Ann Endocrinol (Paris). 1977 Jul-Aug;38(4):255-63.
Plasma concentrations and urinary excretions rate of gonadotropins, testosterone, delta 4-androstenedione, dehydroepiandrosterone and 17 and 17 alpha-hydroxyprogesterone plasma concentrations have been studied in 69 patients with oligo or azoospermia and compared with results obtained in 30 normal control subjects. A sperm count and a caryotype have been done in all patients and a testicular biopsy in 35. Analysis of the histo-hormonal correlations does not show a particular stage of spermatogenesis associated with a modification in FSH production. There is a quantitative relationship between spermatogenesis and FSH production. Plasma testosterone is low and LH production normal in excretory azoospermia. In the other patients plasma testosterone is also low but associated with an increased production of LH. Finally there is a direct relationship between urinary excretion of LH and FSH in both normal subjects and patients, suggesting a modulation by specific factors of a common regulation of the secretion of both gonadotropins.
对69例少精子症或无精子症患者的促性腺激素、睾酮、Δ4-雄烯二酮、脱氢表雄酮的血浆浓度及尿排泄率以及血浆17α-羟孕酮和17-羟孕酮浓度进行了研究，并与30名正常对照者的结果进行了比较。所有患者均进行了精子计数和核型分析，35例患者进行了睾丸活检。组织激素相关性分析未显示与促卵泡激素（FSH）分泌改变相关的特定精子发生阶段。精子发生与FSH分泌之间存在定量关系。在排泄性无精子症患者中，血浆睾酮水平低而促黄体生成素（LH）分泌正常。在其他患者中，血浆睾酮水平也低，但与LH分泌增加有关。最后，正常人和患者的LH和FSH尿排泄之间存在直接关系，提示存在特定因子对两种促性腺激素分泌共同调节的调控作用。
