ARMSTRONG C M, BINSTOCK L
J Gen Physiol. 1965 May;48(5):859-72. doi: 10.1085/jgp.48.5.859.
The injection of tetraethylammonium chloride into the giant axon of the squid prolongs the action potential and eliminates most of the late current under voltage-clamp. Experiments on fibers in an external medium of high potassium ion concentration demonstrate that injected tetraethylammonium chloride causes rectification of the instantaneous current-voltage curve for potassium by excluding outward current. This interference with the flow of outward potassium ion current underlies the prolongation of the action potential seen in tetraethylammonium-injected fibers.
向鱿鱼的巨大轴突中注射氯化四乙铵会延长动作电位，并在电压钳制下消除大部分延迟电流。在高钾离子浓度的外部介质中对神经纤维进行的实验表明，注射的氯化四乙铵通过排除外向电流导致钾离子瞬时电流-电压曲线发生整流。这种对向外钾离子电流流动的干扰是在注射了氯化四乙铵的神经纤维中观察到的动作电位延长的基础。
