Andonopoulos A P, Tzanakakis G N, Christophidou M
Department of Medicine (Division of Rheumatology), Patras University, School of Medicine, Greece.
J Rheumatol. 1992 Sep;19(9):1390-2.
Dried, freshly produced saliva from 21 patients with xerostomia related to the sicca syndrome [15 with primary Sjögren's syndrome (pSS), 3 with rheumatoid arthritis (RA) and secondary Sjögren's syndrome (sSS), and 3 with Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE)] and 21 age and sex matched controls, was examined by light microscopy. A typical fern-like pattern was demonstrated by the crystallized mucus of the healthy individuals. In contrast, much thicker, shorter, irregular and densely arranged branches of crystallized mucus, sometimes giving a reindeer horn appearance, were observed in the patients' saliva. Given the lack of a reliable clinical measure for the objective evaluation of xerostomia, light salivary microscopy, simple and easy as it is, may fill this deficit, if its sensitivity and specificity are documented.
对21例与干燥综合征相关的口干症患者（15例原发性干燥综合征（pSS）、3例类风湿关节炎（RA）合并继发性干燥综合征（sSS）、3例干燥综合征（SS）合并系统性红斑狼疮（SLE））以及21名年龄和性别匹配的对照者的新鲜唾液进行干燥处理后，通过光学显微镜检查。健康个体的结晶黏液呈现出典型的蕨类植物样图案。相比之下，在患者的唾液中观察到结晶黏液的分支更粗、更短、不规则且排列密集，有时呈现出鹿角的外观。鉴于缺乏可靠的临床指标用于客观评估口干症，如果唾液光学显微镜检查的敏感性和特异性得到证实，那么尽管其简单易行，也可能填补这一空白。
