Warren J T, Dolatshahi M
EMMES Corporation, Potomac, MD 20854.
J Med Primatol. 1992 Feb-May;21(2-3):139-86.
An AIDS Vaccine Surveillance System (AVSS) was designed and implemented to track the rapidly growing international database supporting the development of promising AIDS vaccines. Both preclinical nonhuman primate (NHP) and clinical human trials are tracked by the AVSS. This report presents summary data generated from the AVSS on the NHP AIDS vaccine/live virus challenge studies only. Summary data on more than 100 preclinical HIV/SIV vaccines are presented within the framework of 1) 13 arbitrary Vaccine Types, 2) studies grouped by animal model (i.e., chimpanzee/HIV-1, and macaque/SIV, HIV-2), and 3) immunization approach (i.e., active and passive). Systematic and timely presentations of these summary data, both here and in future reports, aim to promote a clearer understanding of both earlier and more recent preclinical AIDS vaccine developments.
设计并实施了艾滋病疫苗监测系统（AVSS），以跟踪快速增长的国际数据库，该数据库为有前景的艾滋病疫苗研发提供支持。AVSS同时跟踪临床前非人类灵长类动物（NHP）试验和人体临床试验。本报告仅呈现AVSS生成的关于NHP艾滋病疫苗/活病毒攻毒研究的汇总数据。100多种临床前HIV/SIV疫苗的汇总数据将在以下框架内呈现：1）13种任意疫苗类型；2）按动物模型分组的研究（即黑猩猩/HIV-1、猕猴/SIV、HIV-2）；3）免疫方法（即主动免疫和被动免疫）。在此处及未来报告中系统且及时地呈现这些汇总数据，旨在促进对早期和近期临床前艾滋病疫苗研发的更清晰理解。
