醛固酮和甲泼尼龙对心脏钠钾ATP酶的影响。
Effect of aldosterone and methylprednisolone on cardiac NaK-ATPase.
作者信息
Hegyvary C
出版信息
Experientia. 1977 Oct 15;33(10):1280-1. doi: 10.1007/BF01920133.
PMID:143369
Abstract
Aldosterone (15 microgram BID) and methylprednisolone (8 mg QD) administration to female guinea-pigs augmented both the total and the specific activity of NaK-ATPase but not the activity of adenylate cyclase in the cardiac sarcolemma. The rise in NaK-ATPase was due to increase in the number of enzyme molecules; catalytic activity and ouabain-sensitivity of individual molecules did not change.
摘要
对雌性豚鼠给予醛固酮（每日两次，每次15微克）和甲泼尼龙（每日一次，每次8毫克），可增强心肌肌膜中钠钾-ATP酶的总活性和比活性，但不会增强腺苷酸环化酶的活性。钠钾-ATP酶活性的升高是由于酶分子数量增加；单个分子的催化活性和哇巴因敏感性并未改变。
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