Ahmad M, Khan A H, Mansoor A, Khan M A, Saeed S
Armed Forces Institute of Pathology (AFIP), Rawalpindi.
J Pak Med Assoc. 1992 Sep;42(9):205-7.
A study of histopathological and clinical features of non-Hodgkin's lymphoma in 495 consecutive cases, diagnosed at AFIP during 1984-1989 is presented. Children below the age of 15 years were not included in this study. The relative frequency of non-Hodgkin's lymphoma was 4.29% in our material. Non-Hodgkin's lymphoma was more frequent than Hodgkin's disease, ratio being 2.44:1. Lymphadenopathy (78.78%), fever (33.08%), weight loss (31.62%) and anemia (30.14%) were the main presenting features. New working formulation was used for morphological characterisation. Follicular lymphoma constituted 8.08% of all cases. Follicular lymphoma was seen only in older age whereas diffuse lymphoma occurred in all age groups. Intermediate and high grade lymphoma represented 73.54% of all NHL. Small lymphocytic lymphoma was common in low grade tumours (13.13%). Extra nodal lymphoma was encountered in a significant proportion (21.22%), gastrointestinal tract being the most frequent site. This study outlines certain interesting features of NHL in Pakistan.
本文介绍了1984年至1989年期间在武装部队病理研究所（AFIP）诊断的495例连续性非霍奇金淋巴瘤病例的组织病理学和临床特征。本研究未纳入15岁以下儿童。在我们的资料中，非霍奇金淋巴瘤的相对发生率为4.29%。非霍奇金淋巴瘤比霍奇金病更常见，比例为2.44:1。淋巴结病（78.78%）、发热（33.08%）、体重减轻（31.62%）和贫血（30.14%）是主要的临床表现。采用新的工作分类法进行形态学特征描述。滤泡性淋巴瘤占所有病例的8.08%。滤泡性淋巴瘤仅见于老年人，而弥漫性淋巴瘤可见于所有年龄组。中高级别淋巴瘤占所有非霍奇金淋巴瘤的73.54%。小淋巴细胞淋巴瘤在低级别肿瘤中常见（13.13%）。结外淋巴瘤占相当比例（21.22%），胃肠道是最常见的部位。本研究概述了巴基斯坦非霍奇金淋巴瘤的某些有趣特征。
