Katada T, Ui M
Diabetologia. 1977 Sep;13(5):521-5. doi: 10.1007/BF01234507.
Following the intravenous injection of streptozotocin into rats, postprandial hyperglycaemia was sustained from 24 hours over a subsequent period of some weeks and the rats were glucose intolerant. When streptozotocin was similarly injected into pertussis-sensitized or hydrocortisone treated rats, the postprandial hyperglycaemia observed at 24 hours did not persist, but showed a progressive decline until near normoglycaemia was obtained a week later. These animals manifested normal glucose tolerance one week after streptozotocin. Thus, a spontaneous recovery from streptozotocin-induced diabetes occurred under these conditions. This spontaneous recovery from diabetes was associated with hyperinsulinaemia in the fed state.
给大鼠静脉注射链脲佐菌素后，餐后高血糖在随后的几周内从24小时起持续存在，并且大鼠出现葡萄糖不耐受。当以同样方式给百日咳致敏或氢化可的松处理的大鼠注射链脲佐菌素时，24小时时观察到的餐后高血糖并未持续，而是逐渐下降，直到一周后血糖接近正常水平。这些动物在注射链脲佐菌素一周后表现出正常的葡萄糖耐量。因此，在这些条件下，链脲佐菌素诱导的糖尿病出现了自发恢复。糖尿病的这种自发恢复与进食状态下的高胰岛素血症有关。
