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地中海链霉菌对巴比妥的代谢

METABOLISM OF BARBITAL BY STREPTOMYCES MEDITERRANEI.

作者信息

KLUEPFEL D, LANCINI G C, SARTORI G

出版信息

Appl Microbiol. 1965 Jul;13(4):600-4. doi: 10.1128/am.13.4.600-604.1965.

DOI:10.1128/am.13.4.600-604.1965
PMID:14339268
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1058304/
Abstract

The metabolism of barbital in cultures of Streptomyces mediterranei was studied. Small quantities were transformed during the fermentation. Four compounds were isolated and identified as 5-ethyldialuric acid, 5-ethylbarbituric acid, 5-(beta-hydroxyethyl)-5-ethylbarbituric acid, and diethylmalonic acid monoureid. The influence of these compounds on the production of rifamycin was of minor importance. With the aid of C(14)-barbital, it was established that neither barbital nor any of its metabolic products can be considered as precursors of the rifamycin B.

摘要

研究了巴比妥在地中海链霉菌培养物中的代谢情况。发酵过程中有少量巴比妥发生了转化。分离并鉴定出了四种化合物，分别为5-乙基二脲酸、5-乙基巴比妥酸、5-(β-羟乙基)-5-乙基巴比妥酸和二乙基丙二酸单脲。这些化合物对利福霉素产量的影响较小。借助C(14)-巴比妥证实，巴比妥及其任何代谢产物都不能被视为利福霉素B的前体。

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本文引用的文献

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