Saito Y
Department of Medical Chemistry, Faculty of Medicine, Kyoto University.
Nihon Rinsho. 1992 Aug;50(8):1776-80.
The Interleukin 2 receptor is now assumed to be composed of three chains, the L (alpha or Tac), H (beta) chain and p56. The L chain binds IL-2 with low affinity, whereas intermediate-affinity binding of IL-2 is achieved by an association of p56 and the H chain. The high-affinity IL-2R is therefore believed to be a quaternary complex composed of the L chain, the H chain, p56 and IL-2. A larger number of L chains enhances the association rate of IL-2 to form the high-affinity IL-2R in agreement with the stepwise binding model. The signal transduction-competent H chain has been shown to associate with p56lck upon IL-2 stimulation.
白细胞介素2受体现被认为由三条链组成，即L（α或Tac）链、H（β）链和p56。L链以低亲和力结合白细胞介素2，而白细胞介素2的中等亲和力结合是通过p56与H链的缔合实现的。因此，高亲和力白细胞介素2受体被认为是由L链、H链、p56和白细胞介素2组成的四聚体复合物。与逐步结合模型一致，大量的L链可提高白细胞介素2形成高亲和力白细胞介素2受体的缔合速率。已证明具有信号转导能力的H链在白细胞介素2刺激后会与p56lck缔合。
