Katoh S, Takatsu K
Department of Immunology, Oklahoma Medical Research Center.
Nihon Rinsho. 1992 Aug;50(8):1795-801.
IL-5 is a T-cell-derived glycoprotein that acts on B cells and eosinophils to induce their growth and differentiation. We clarified using in vitro long-term bone marrow culture that IL-5 supports the growth and survival of Ly-1+ common progenitor cells which can differentiate into Ly-1+ B cells and Ly-1+ macrophages. The functional IL-5 receptor (IL-5R) consists of alpha and beta heterodimers. The 60 kDa alpha chain binds to IL-5 with low affinity, while the 130 kDa beta chain does not bind with IL-5 by itself, but converts low affinity IL-5R to high affinity IL-5R together with the alpha chain. The beta chain is shared with GM-CSFR and IL-3R.
白细胞介素-5是一种由T细胞产生的糖蛋白，作用于B细胞和嗜酸性粒细胞，诱导其生长和分化。我们通过体外长期骨髓培养明确，白细胞介素-5支持Ly-1 +共同祖细胞的生长和存活，这些祖细胞可分化为Ly-1 + B细胞和Ly-1 +巨噬细胞。功能性白细胞介素-5受体（IL-5R）由α和β异二聚体组成。60 kDa的α链以低亲和力结合白细胞介素-5，而130 kDa的β链自身不与白细胞介素-5结合，但与α链一起将低亲和力的IL-5R转化为高亲和力的IL-5R。β链与GM-CSFR和IL-3R共用。
