Gamou S, Shimizu N
Department of Molecular Biology, Keio University School of Medicine.
Nihon Rinsho. 1992 Aug;50(8):1885-92.
Epidermal growth factor (EGF) binds to the specific membrane receptor and subsequently activates the signal transduction pathway through intrinsic tyrosine kinase activity. To elucidate the mechanism in which structural alteration of the EGF may affect functional properties including its receptor binding ability, site-directed mutagenesis has been employed. The functional significance of structural characteristics of the EGF receptor has been studied also by mutant receptor constructs in the transfected cells. Recent progress on the studies of the EGF and EGF receptor interaction are reviewed.
表皮生长因子（EGF）与特定的膜受体结合，随后通过内在的酪氨酸激酶活性激活信号转导途径。为了阐明EGF结构改变可能影响其功能特性（包括受体结合能力）的机制，已采用定点诱变技术。通过转染细胞中的突变受体构建体，也对EGF受体结构特征的功能意义进行了研究。本文综述了EGF与EGF受体相互作用研究的最新进展。
