Tomida M
Saitama Cancer Center Research Institute.
Nihon Rinsho. 1992 Aug;50(8):1956-61.
Differentiation-stimulating factor (D-factor)/leukemia inhibitory factor (LIF) is a cytokine inducing differentiation of mouse myeloid leukemic M1 cells. IL-6, oncostatin M (OSM) and G-CSF also induce differentiation of M1 cells. These four cytokines are suggested to be members of a single cytokine family. The LIF receptor is structurally related to the gp130 signal-transducing component of the IL-6 receptor and to the G-CSF receptor. The high-affinity receptors for LIF, OSM and IL-6 share the common subunit, gp130. This provides an explanation for the functional redundancy of those cytokines.
分化刺激因子（D因子）/白血病抑制因子（LIF）是一种可诱导小鼠髓系白血病M1细胞分化的细胞因子。白细胞介素-6（IL-6）、制瘤素M（OSM）和粒细胞集落刺激因子（G-CSF）也可诱导M1细胞分化。这四种细胞因子被认为是单一细胞因子家族的成员。LIF受体在结构上与IL-6受体的gp130信号转导成分以及G-CSF受体相关。LIF、OSM和IL-6的高亲和力受体共享共同的亚基gp130。这就解释了这些细胞因子的功能冗余性。
