Igarashi T
Tokyo University.
Nihon Rinsho. 1992 Sep;50(9):2199-205.
Renal tubular acidosis (RTA) can be separated into three main types: distal RTA (the defect in the excretion of hydrogen ion), proximal RTA (the defect in the reabsorption of bicarbonate), and hyperkalemic RTA. Some patients present combined types of proximal and distal RTA. Most of the pediatric patients with RTA manifest failure to thrive. They have hyperchloremic metabolic acidosis and normal plasma anion gap. Fractional excretion of bicarbonate is below 5% in dRTA and over 15% in pRTA. Renal complications of dRTA are nephrocalcinosis, renal calculi, renal cysts and reversible low molecular weight proteinuria. The patient with isolated pRTA is very rare.
肾小管酸中毒(RTA)可分为三种主要类型:远端肾小管酸中毒(氢离子排泄缺陷)、近端肾小管酸中毒(碳酸氢盐重吸收缺陷)和高钾型肾小管酸中毒。一些患者表现为近端和远端肾小管酸中毒的联合类型。大多数患有肾小管酸中毒的儿科患者表现为发育不良。他们有高氯性代谢性酸中毒且血浆阴离子间隙正常。在远端肾小管酸中毒中,碳酸氢盐的排泄分数低于5%,而在近端肾小管酸中毒中则超过15%。远端肾小管酸中毒的肾脏并发症有肾钙质沉着、肾结石、肾囊肿和可逆性低分子量蛋白尿。孤立性近端肾小管酸中毒的患者非常罕见。