Tateno M, Nakano A, Hasegawa A, Watanabe N, Oriuchi N, Inoue T, Endo K, Sasaki Y
Department of Nuclear Medicine, Gunma University School of Medicine.
Kaku Igaku. 1992 May;29(5):585-90.
Alveolar epithelial permeability was assessed in 32 patients with progressive systemic scleroderma (PSS), using 99mTc-DTPA aerosol. Immediately after the inhalation of 99mTc-DTPA aerosol for 3 to 6 minutes under normal tidal breathing, lung was imaged sequentially for 30 minutes from the posterior by a gamma camera and exponential fitting was processed on the time activity curve. T1/2 (min) was used as a parameter for the evaluation of permeability of alveolar epithelium. Patients with collagen disease showed shorter T1/2 (T1/2 = 43.7 +/- 23.8 min) than the normal volunteers (T1/2 = 76.8 +/- 8.7 min). No significant difference was observed between patients with or without interstitial changes on the chest CT. Significant correlation was not observed between T1/2 and %VC or %DLco. In 8 cases, studies were repeated in the interval of 3 to 19 months. Improvement of T1/2 was seen in 4 cases, independent of CT findings. These results suggest that 99mTc-DTPA aerosol clearance study provides information independent from other lung examinations, and may be useful for the assessment of lung interstitial changes in patients with PSS.
采用99mTc - DTPA气雾剂对32例进行性系统性硬化症（PSS）患者的肺泡上皮通透性进行评估。在正常潮式呼吸下吸入99mTc - DTPA气雾剂3至6分钟后，立即用γ相机从后位对肺部进行30分钟的连续成像，并对时间 - 活性曲线进行指数拟合。T1/2（分钟）用作评估肺泡上皮通透性的参数。胶原病患者的T1/2（T1/2 = 43.7 +/- 23.8分钟）比正常志愿者（T1/2 = 76.8 +/- 8.7分钟）短。胸部CT有或无间质改变的患者之间未观察到显著差异。T1/2与%VC或%DLco之间未观察到显著相关性。8例患者在3至19个月的间隔内重复进行了研究。4例患者的T1/2有所改善，与CT结果无关。这些结果表明，99mTc - DTPA气雾剂清除率研究提供了独立于其他肺部检查的信息，可能有助于评估PSS患者的肺间质改变。
