多环化合物的代谢。大鼠肝脏匀浆对7,12-二甲基苯并（α）蒽的代谢
METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 7,12-DIMETHYLBENZ(ALPHA)ANTHRACENE BY RAT-LIVER HOMOGENATES.
作者信息
BOYLAND E, SIMS P
出版信息
Biochem J. 1965 Jun;95(3):780-7. doi: 10.1042/bj0950780.
Abstract
- The main products of the metabolism of 7,12-dimethylbenz[a]anthracene by rat-liver homogenates are the isomeric monohydroxymethyl derivatives. The syntheses of these compounds are described. 2. Two phenolic products and two dihydrodihydroxy compounds were formed, but none of these appeared to have been formed by hydroxylation at the ;K region'. There was little evidence for the formation of a glutathione conjugate of the hydrocarbon. 3. The monohydroxymethyl derivatives are products of the hydroxylation of the hydrocarbon in the ascorbic acid-Fe(2+)-oxygen model hydroxylating system.
摘要
- 大鼠肝脏匀浆对7,12 - 二甲基苯并[a]蒽进行代谢的主要产物是异构的单羟甲基衍生物。描述了这些化合物的合成方法。2. 形成了两种酚类产物和两种二氢二羟基化合物，但这些产物似乎都不是通过在“K区域”羟基化形成的。几乎没有证据表明该烃形成了谷胱甘肽缀合物。3. 单羟甲基衍生物是抗坏血酸 - 铁（Ⅱ） - 氧模型羟基化系统中该烃羟基化的产物。
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