Cavalieri E, Calvin M
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1251-3. doi: 10.1073/pnas.68.6.1251.
The chemical reactivity and presumably the carcinogenic activity induced in aromatic hydrocarbons by hydroxylating enzymes may be due to the generation of electrophilic centers in some (benzo[a]pyrene) or nucleophilic centers in others (7,12-dimethylbenz[a]anthracene or 3-methylcholanthrene). These centers, which are at positions complementary to the points of activation by acid-derived protons (models of the positive oxygen of the hydroxylating enzymes), may react simultaneously with corresponding cellular components.
羟化酶在芳香烃中诱导产生的化学反应性以及可能的致癌活性,可能是由于在某些物质(苯并[a]芘)中产生亲电中心,而在其他物质(7,12-二甲基苯并[a]蒽或3-甲基胆蒽)中产生亲核中心。这些中心位于与酸衍生质子的活化点互补的位置(羟化酶正氧的模型),可能会同时与相应的细胞成分发生反应。