Polliack A, Lugassy G
Department of Hematology, Hadassah University Hospital, Jerusalem, Israel.
Leukemia. 1992 Nov;6 Suppl 4:152-4.
In this report the association of autoimmunity and autoimmune syndromes with lymphoproliferative disorders (LPD) is described in 15 patients. Non-Hodgkin's lymphoma (NHL) developed in 10 patients, Hodgkin's disease (HD) in 3 and chronic lymphocytic leukemia (CLL) in two. In most instances clinical and laboratory phenomena preceded the development/diagnosis of these disorders. Manifestations ranged from the presence of autoantibodies in the serum to the presence of both ill defined or incomplete autoimmune syndromes including cold urticaria, Raynaud's phenomenon, cold agglutinin disease, thyroiditis, nephrotic syndrome and vasculitis to typical systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and even one of scleroderma. It is suggested that in some patients (in)complete clinical manifestations of autoimmunity may precede the development of lymphoid neoplasias. The link between autoimmunity and lymphoproliferative disorders is briefly discussed.
在本报告中，描述了15例自身免疫及自身免疫综合征与淋巴增殖性疾病（LPD）的关联。10例患者发生了非霍奇金淋巴瘤（NHL），3例发生了霍奇金病（HD），2例发生了慢性淋巴细胞白血病（CLL）。在大多数情况下，临床和实验室现象先于这些疾病的发生/诊断。表现范围从血清中自身抗体的存在到不明确或不完全的自身免疫综合征，包括寒冷性荨麻疹、雷诺现象、冷凝集素病、甲状腺炎、肾病综合征和血管炎，再到典型的系统性红斑狼疮（SLE）、类风湿关节炎（RA），甚至硬皮病中的一种。提示在一些患者中，自身免疫的（不）完全临床表现可能先于淋巴肿瘤的发生。本文简要讨论了自身免疫与淋巴增殖性疾病之间的联系。
