致癌物二甲基亚硝胺在完整动物体内与蛋白质及硫醇化合物的反应。
REACTION OF THE CARCINOGEN DIMETHYLNITROSAMINE WITH PROTEINS AND WITH THIOL COMPOUNDS IN THE INTACT ANIMAL.
作者信息
CRADDOCK V M
出版信息
Biochem J. 1965 Feb;94(2):323-30. doi: 10.1042/bj0940323.
Abstract
- [(14)C]Dimethylnitrosamine was administered to rats, and the formation of free and protein-bound S-methylcysteine was investigated. 2. Very little S-methylcysteine was found in liver acid-soluble fraction, in liver protein or in urine. 3. The methylhistidines formed in liver protein were found to have largely disappeared by 6 days after injection of dimethylnitrosamine. 4. The significance of these results in the carcinogenic action of dimethylnitrosamine is discussed.
摘要
- 给大鼠注射[(14)C]二甲基亚硝胺，并研究游离和与蛋白质结合的S-甲基半胱氨酸的形成。2. 在肝脏酸溶性部分、肝脏蛋白质或尿液中发现的S-甲基半胱氨酸极少。3. 发现肝脏蛋白质中形成的甲基组氨酸在注射二甲基亚硝胺后6天基本消失。4. 讨论了这些结果在二甲基亚硝胺致癌作用中的意义。
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