Douvlis Z
Med Hypotheses. 1992 Sep;39(1):73-84. doi: 10.1016/0306-9877(92)90144-2.
The hypothesis put forward here is that during the growth of a primary tumor ending in metastasis formation, phases occur in which 'unfavourable' conditions arise for the tumor cells. It is proposed that, in order to overcome these 'unfavourable' situations, the tumor cells subsequently secrete a substance designed to have a 'dysfunctional' effect on the normal cells. On the assumption of such a discontinuous secretion by the tumor cells, an investigation is made into the behaviour of certain tumors in humans, together with the findings of previously conducted tests. This leads to the formulation of possible concepts for prophylaxis and treatment. In conclusion, an attempt is made to locate what would be the precise target of such a hypothetical substance.
本文提出的假说是，在以转移形成为结局的原发性肿瘤生长过程中，会出现一些对肿瘤细胞“不利”的阶段。有人提出，为了克服这些“不利”情况，肿瘤细胞随后会分泌一种对正常细胞具有“功能失调”作用的物质。基于肿瘤细胞这种不连续分泌的假设，对人类某些肿瘤的行为以及先前进行的测试结果进行了研究。这导致了预防和治疗的可能概念的形成。总之，试图确定这种假设物质的确切靶点。
